Not only have I heard of Protandim, but I was the spokesperson for the product the first year it came out. Dr. Joe McCord, the researcher that first discovered the antioxidant enzyme, superoxide dismutase, developed the supplement. It is not an antioxidant, but rather affects gene expression, turning on the cells’ production of antioxidant enzymes, much like all colorful fruits/vegetables, turmeric, etc do. It won’t give you energy. There are studies to support its use. Several years ago, I guessed it was the first of a new wave of supplements that will take advantage of this new area in nutrition, nutragenomics, which is the study of how food affects gene expression. The problem is most people don’t understand how foods affect cellular DNA, and the supplement, Protandim, was expensive. It’s a great supplement and I trust the researcher and the research to support its use. I know of no negative side effects.